fenpentadiol

  • CasNo：15687-18-0
  • purity：99%
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Details

fenpentadiol 15687-18-0 with purity >99% Low price in stock

  • Molecular Formula: C12H17 Cl O2
  • Molecular Weight: 228.719
  • Vapor Pressure: 6.29E-06mmHg at 25°C 
  • Melting Point: 76.5℃ 
  • Refractive Index: 1.5434 (estimate) 
  • Boiling Point: 363.7°Cat760mmHg 
  • PKA: 14.36±0.29(Predicted) 
  • Flash Point: 173.8°C 
  • PSA： 40.46000 
  • Density: 1.166g/cm3 
  • LogP: 2.70850 

fenpentadiol(Cas 15687-18-0) Usage

Manufacturing Process

2-(p-Chlorophenyl)-4-methylpentane-2,4-diol (M.P. 76.5°C) was synthesized and condensation of 2-(p-chlorophenyl)-3-hydroxybytiric acid ethyl ester with CH3 MgI in ether.

Therapeutic Function

Antidepressant, Tranquilizer

InChI:InChI=1/C12H17ClO2/c1-11(2,14)8-12(3,15)9-4-6-10(13)7-5-9/h4-7,14-15H,8H2,1-3H3

15687-18-0 Relevant articles

Triflimide: An Overlooked High-Performance Catalyst of the Mukaiyama Aldol Reaction of Silyl Ketene Acetals with Ketones

Bae, Han Yong,List, Benjamin

, p. 13767 - 13772 (2018/09/12)

The Mukaiyama aldol reaction is a widely...

15687-18-0 Process route

4-((tert-butyldimethylsilyl)oxy)-4-(4-chlorophenyl)-2-methylpentan-2-ol

4-((tert-butyldimethylsilyl)oxy)-4-(4-chlorophenyl)-2-methylpentan-2-ol

2-(4-chlorophenyl)-4-methylpentane-2,4-diol
15687-18-0

2-(4-chlorophenyl)-4-methylpentane-2,4-diol

Conditions
Conditions Yield
With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 6h;
81%
para-chloroacetophenone
99-91-2

para-chloroacetophenone

2-(4-chlorophenyl)-4-methylpentane-2,4-diol
15687-18-0

2-(4-chlorophenyl)-4-methylpentane-2,4-diol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: Zn / benzene; toluene / Heating
2: diethyl ether
With zinc; In diethyl ether; toluene; benzene;
Multi-step reaction with 3 steps
1.1: bis(trifluoromethanesulfonyl)amide / diethyl ether / -78 - 23 °C / Schlenk technique; Inert atmosphere
1.2: 0.5 h / -20 °C / Schlenk technique; Inert atmosphere
2.1: dichloromethane / 24 h / 0 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 0 °C
With tetrabutyl ammonium fluoride; bis(trifluoromethanesulfonyl)amide; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: |Mukaiyama Aldol Addition / 1.2: |Mukaiyama Aldol Addition;

15687-18-0 Upstream products

  • 917-64-6
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    methyl magnesium iodide

  • 21133-98-2
    21133-98-2

    ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate

  • 99-91-2
    99-91-2

    para-chloroacetophenone

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