Monoethyl fumarate

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1.What is the Monoethyl fumarate ?

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ChEBI: Monomethyl fumarate is a dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1. It has a role as an immunomodulator, an antioxidant and a drug metabolite. It is an enoate ester, a methyl ester and a dicarboxylic acid monoester. It derives from a fumaric acid.

Monoethyl fumarate is the Monoethyl ester form of fumarate. It is a kind of effective preservative and polymerization agent for macromolecular material. Monoethyl fumarate is capable of inhibiting the growth of bacteria, yeast and mold and prolonging the storage time of feed can. It can also be used for long-term systemic therapy in the treatment of psoriasis (a chronic hyperproliferative inflammatory skin disorder). It is the most active ingredient in the antipsoriasis drug Fumadem. The mechanism is likely to be related to its effect of improvement of keratinocyte differentiation and inhibition of keratinocyte proliferation. Monomethyl fumarate has beneficial effects on the inflamed blood–brain barrier. It increases levels of endogenous antioxidant proteins in brain endothelial cells and reduces expression of VCAM-1 in inflamed brain endothelial cells. Transendothelial monocyte migration is limited upon MMF treatment.

2.What is the CAS number for Monoethyl fumarate ?

The CAS number of Monoethyl fumarate is 2459-05-4.

3.What are another words for Monoethyl fumarate ?

Synonyms?for?Monoethyl fumarate 2459-05-4:2-Butenedioicacid (2E)-, monoethyl ester (9CI);2-Butenedioic acid (E)-, monoethyl ester;Fumaric acid, ethyl ester (6CI,7CI);Fumaric acid, monoethyl ester (8CI);(E)-4-Ethoxy-4-oxo-2-butenoic acid;Ethyl hydrogen fumarate;Monoethylfumarate;Monoethyl trans-2-butenedioate;

4.What is Monoethyl fumarate (2459-05-4) used for?

Monoethyl fumarate is the monoethyl ester form of fumaric acid. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material.Monoethyl fumarate (fumaric acid monoethyl ester, monoethyl fumarate) was used in the preparation of photo-crosslinkable macromers. It was also used to synthesize Ugi/intramolecular Diels-Alder (IMDA) cycloaddition products.

InChI:InChI=1/C6H8O4/c1-2-10-6(9)4-3-5(7)8/h3-4H,2H2,1H3,(H,7,8)/p-1

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5.Buy Monoethyl fumarate with the best price .

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